Yes, Xanax withdrawal can cause muscle spasms. Muscle twitching and spasms are common symptoms of benzodiazepine withdrawal, which Xanax belongs to. Benzodiazepine withdrawal can cause changes in the activity of neurotransmitters in the brain, which can result in symptoms such as muscle spasms, tremors, and convulsions. It is important to seek medical attention if you experience any withdrawal symptoms after stopping Xanax, as withdrawal can be dangerous and potentially life-threatening.