There is no evidence that Adderall use causes brain damage or kills brain cells. However, long-term abuse of Adderall can lead to physical and psychological dependence, which can cause a range of adverse effects on both the brain and body. These can include insomnia, irritability, paranoia, anxiety, and even depression. It’s important to use Adderall only as prescribed by a qualified medical professional and to follow all instructions and guidelines for safe and responsible use.