Yes, clonidine can cause withdrawal if it is stopped abruptly after regular use for a prolonged period. Clonidine is a medication that is commonly used to treat high blood pressure, attention deficit hyperactivity disorder (ADHD), and other conditions. It works by slowing down the heart rate and reducing blood pressure by stimulating alpha-adrenergic receptors in the brain. Prolonged use of clonidine can lead to physical dependence, and sudden discontinuation can cause withdrawal symptoms such as high blood pressure, agitation, tremors, anxiety, rapid heart rate, and sweating. It is essential to follow your doctor’s instructions carefully when using clonidine and to gradually reduce the dose under medical supervision when stopping the medication.