1(800) 615-1067Pristiq (desvenlafaxine) withdrawal symptoms can last for a few weeks to several months, depending on various factors such as the duration and dosage of the medication, individual differences in metabolism, and the method of discontinuation. The symptoms can include mood swings, irritability, anxiety, dizziness, nausea, and sleep disturbances. It is important to consult with a healthcare provider before discontinuing Pristiq or any other medication to develop a safe and effective tapering plan to avoid or minimize withdrawal symptoms.