The Sinclair Method (TSM) is a treatment method for alcohol addiction that involves taking an opioid-blocking medication, such as naltrexone, before drinking alcohol. Here’s how the Sinclair Method works:

Take the medication: Before drinking alcohol, the individual takes a dose of the opioid-blocking medication, such as naltrexone.

Drink alcohol: The individual then drinks alcohol as they normally would, without any restrictions.

Gradual extinction: Over time, the individual’s desire to drink alcohol gradually decreases, as their brain no longer receives the same level of pleasure or reward from alcohol.

Reduced cravings: As the individual continues to take the medication before drinking, their cravings for alcohol become less intense, and they may begin to drink less frequently or in smaller amounts.

Long-term sobriety: With continued use of the medication, the individual may be able to achieve long-term sobriety, without the need for traditional addiction treatment methods, such as abstinence-based programs or counseling.

The Sinclair Method is based on the idea of “pharmacological extinction,” which involves using medication to gradually reduce the desire to drink alcohol, rather than relying on willpower or abstinence. The medication works by blocking the release of endorphins in the brain that are associated with the pleasurable effects of alcohol, reducing the reinforcing effects of drinking.

It’s important to note that the Sinclair Method should only be used under the supervision of a qualified healthcare provider and is not suitable for everyone. The method may not be effective for individuals with severe alcohol addiction or other underlying mental health conditions.