The Sinclair Method is a treatment method for alcohol addiction that involves taking a medication called naltrexone before drinking alcohol. Naltrexone is an opioid antagonist that blocks the endorphin rush that is typically associated with alcohol consumption, which in turn reduces the craving for alcohol. The idea is that over time, the individual will become less dependent on alcohol as they are no longer experiencing the same pleasurable effects that they may have once associated with drinking. The Sinclair Method is often used in conjunction with counseling and other forms of support, and has been shown to be effective in helping people reduce or eliminate their alcohol use.