The United States Medical Licensing Examination (USMLE) Step 1 no longer uses the terms “substance abuse” and “substance dependence” to classify substance-related disorders. Instead, the USMLE currently uses the term “substance use disorder” to encompass the full range of substance-related disorders, from mild to severe. The criteria for diagnosing a substance use disorder are based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), which replaced the previous terms of “substance abuse” and “substance dependence” with a continuum of substance use disorders based on the severity of the symptoms.