Substance abuse with psychosis refers to the co-occurrence of a substance use disorder and a psychotic disorder. Substance abuse can trigger or worsen psychotic symptoms, such as hallucinations, delusions, and disordered thinking. Psychotic disorders that commonly co-occur with substance abuse include schizophrenia, bipolar disorder with psychotic features, and severe forms of depression. Effective treatment typically involves addressing both the substance use disorder and the psychotic disorder through a combination of medication and therapy.