1(800) 615-1067Withdrawal symptoms from Paxil (paroxetine) can start within hours or days of stopping the medication, depending on the dose, duration of treatment, and individual factors. In general, the half-life of Paxil is about 24 hours, meaning it takes about a day for half of the drug to be eliminated from the body. Withdrawal symptoms can last for several weeks or longer, and can include anxiety, depression, irritability, agitation, dizziness, fatigue, headaches, nausea, diarrhea, sweating, and insomnia. It’s important to work closely with a healthcare provider to safely taper off Paxil and manage withdrawal symptoms.