Naloxone should be administered immediately in the event of a suspected opioid overdose. Signs of an opioid overdose include slowed or stopped breathing, blue or gray skin color, unresponsiveness or inability to wake up, and pinpoint pupils. If these symptoms are present, it is critical to call emergency services and administer naloxone if available. Naloxone can reverse the effects of an opioid overdose and save a person’s life.