1(800) 615-1067Naloxone should be used in cases of suspected or known opioid overdose to reverse the life-threatening respiratory depression caused by opioids. It can be given in both pre-hospital and hospital settings by emergency medical services (EMS) personnel, first responders, or trained laypersons, as well as healthcare professionals. It is important to note that naloxone is not a substitute for emergency medical care and that individuals who receive naloxone should still seek medical attention immediately, as the effects of the opioid can return after the naloxone wears off.