Naloxone is a medication that is used to reverse the effects of opioid overdose. It works by binding to the same receptors in the brain that opioids bind to, thereby blocking the effects of the opioids and reversing the overdose.

As far as my knowledge cutoff date, April 2023, naloxone is manufactured by several pharmaceutical companies around the world. Some of the major manufacturers of naloxone include Hospira, Inc., Amphastar Pharmaceuticals, Inc., and Mylan N.V.

Naloxone is available in different forms, including injectable solutions, nasal sprays, and auto-injectors, and it can be distributed through various channels, such as hospitals, pharmacies, and community-based harm reduction programs.

In recent years, there has been increased advocacy and awareness around the importance of making naloxone more widely available to individuals who may be at risk of opioid overdose, including people who use drugs and their loved ones. Many governments and public health agencies have implemented naloxone distribution programs to increase access to this life-saving medication.