Substance abuse and addiction are significant risk factors for suicide, and individuals with substance use disorders are at an increased risk of suicidal behavior. However, it is difficult to determine which specific addiction has the highest suicide rate, as suicide is a complex issue that can be influenced by a variety of factors.

According to the American Foundation for Suicide Prevention, individuals with alcohol use disorders are at a higher risk of suicide than the general population, with studies suggesting that up to 20% of individuals with alcohol use disorder may attempt suicide at some point in their lives. Additionally, individuals with opioid use disorder may also be at an increased risk of suicide, particularly in the context of opioid withdrawal or when experiencing depression or other mental health conditions.

It is important to note that suicide prevention requires a comprehensive approach that addresses the underlying factors contributing to suicidal behavior, such as mental health conditions and substance abuse, and promotes access to effective treatment and support services.