Substance abuse is more common in males than females due to a variety of biological, psychological, and social factors. One possible reason is that men have higher levels of testosterone, which has been linked to increased risk-taking behaviors, including substance abuse. Additionally, social norms and expectations around masculinity may contribute to higher rates of substance abuse in men, as they may feel pressure to use drugs or alcohol as a way to cope with stress or appear tough or cool. However, it is important to note that substance abuse can affect anyone, regardless of gender.