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Percocet (oxycodone and acetaminophen) can cause kidney problems, especially when used for long periods of time or at high doses. Acetaminophen, one of the active ingredients in Percocet, can cause damage to the kidneys when taken in excess or for prolonged periods. The risk of kidney damage is higher in people with pre-existing kidney disease, liver disease, or those who drink large amounts of alcohol.

Symptoms of kidney problems may include decreased urine output, swelling in the legs and feet, nausea, vomiting, and fatigue. If you experience any of these symptoms while taking Percocet, it is important to talk to your healthcare provider. They may recommend blood tests or other diagnostic tests to evaluate your kidney function and determine if Percocet is causing any damage.

To reduce the risk of kidney damage, it is important to take Percocet only as directed by a healthcare provider and to avoid taking more than the prescribed dose. It is also important to drink plenty of water and to avoid alcohol while taking Percocet. If you have pre-existing kidney disease or other health conditions that may increase your risk of kidney damage, your healthcare provider may monitor your kidney function more closely while you are taking Percocet.