Withdrawal symptoms from Pristiq (desvenlafaxine) can vary in duration and severity depending on the individual, their dosage, and the length of time they have been taking the medication. Generally, Pristiq withdrawal symptoms can last for a few weeks to several months after the last dose. Common symptoms may include dizziness, nausea, headache, irritability, anxiety, insomnia, and fatigue. It is important to speak with a healthcare provider about any concerns regarding Pristiq withdrawal and to work with a healthcare team to gradually taper off the medication to minimize the risk of withdrawal symptoms.