Yes, withdrawal from antidepressants can cause headaches as one of the withdrawal symptoms. Antidepressant medications work by altering the levels of certain chemicals in the brain called neurotransmitters, and when a person stops taking the medication abruptly or too quickly, it can lead to a sudden drop in the levels of these chemicals, which can cause a range of symptoms, including headaches. It is recommended to taper off antidepressants gradually under medical supervision to minimize the risk of withdrawal symptoms.