Substance abuse can become a problem when it begins to interfere with a person’s daily life and responsibilities. This can include problems at work or school, difficulties in personal relationships, and negative effects on physical and mental health. Substance abuse can also become a problem when it leads to addiction, which is a chronic, relapsing disorder characterized by compulsive drug seeking and use despite harmful consequences. It is important to seek help if substance abuse is causing problems in your life or the life of someone you know.